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The dental implant therapy has evolved both in implant surface and design. The reason for the initial crestal bone loss has been proven and the risks of having a peri-implantitis have increased due to the early exposure of roughened surface. The prevalence of peri-implantitis is at a range of 28 to 56%. The role of dental professionals nowadays is to know how to interpret the signs of inflammation and establish the diagnosis of peri-implantitis, which is the most challenging, and be able to treat it properly since this is becoming a more needed therapy.